Statin-associated myopathy and its exacerbation with exercise.

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are a common and effective treatment for hypercholesterolemia, with a low overall rate of side-effects. The most common complication is some degree of skeletal muscle myopathy, ranging from painless serum creatine kinase elevations to rhabdomyolysis. Unfortunately, the likelihood and/or severity of complications increases with the combination of statin treatment and physical activity. The specific pathways that mediate statin-associated myopathy are unclear, and research directly addressing the exacerbation with exercise is limited. Potential mechanisms include the induction of skeletal muscle fiber apoptosis, alterations in ubiquitin-proteasome pathway activity, mitochondrial dysfunction, and terpenoid depletion. In this review we provide an overview of research that specifically addresses the combination of statin-associated myopathy and physical activity and highlight some deficiencies in the available literature, as well as future directions for this important subset of statin-associated myopathy.

• Authors: Benjamin M Meador, Kimberly A Huey
• Journal: Muscle & nerve (Muscle Nerve) Vol. 42 Issue 4 Pg. 469-79 (Oct 2010) ISSN: 1097-4598 [Electronic] United States
• PMID: 20878737 (Publication Type: Journal Article, Review)

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Glycogen
• Creatine Kinase

Topics

• Creatine Kinase (blood)
• Exercise
• Glycogen (metabolism)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects, therapeutic use)
• Hypercholesterolemia (drug therapy)
• Muscle, Skeletal (metabolism)
• Muscular Diseases (etiology, physiopathology)
• Physical Education and Training
• Risk Assessment
• Risk Factors