Abstract | STUDY OBJECTIVE: DESIGN: Pharmacokinetic analysis. SETTING: PATIENTS: MEASUREMENTS AND MAIN RESULTS: Plasma samples were collected from the two patients before and 30 minutes after the fourth (first patient) and ninth (second patient) peramivir infusion to estimate minimum (C(min)) and maximum (C(max)) plasma concentrations, respectively. Two additional postinfusion concentrations were measured from each patient to estimate noncompartmental pharmacokinetic parameters of peramivir while receiving CVVHDF. In the two patients, respectively, C(min) was 2170 and 251 ng/ml, C(max) was 18,400 and 20,300 ng/ml, area under the plasma concentration-time curve from 0-24 hours (AUC(0-24)) was 178,000 and 94,400 ng·hour/ml, drug clearance was 56 and 106 ml/minutes, and plasma half-life was 7.6 and 3.7 hours. The volume of distribution adjusted for ideal body weight at steady state was 0.51 and 0.54 L/kg, respectively. CONCLUSION: The first patient had a slower peramivir plasma clearance compared with the second patient, but both patients had higher peramivir clearances as calculated from AUC(0-24) than those predicted by CRRT. Thus, the dosage of intravenous peramivir was appropriate in these patients. Additional pharmacokinetic data are needed to confirm these results and help guide dosing in patients receiving various forms of CRRT.
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Authors | Jose A Bazan, Karri A Bauer, Alan S Hollister, Ganesh Shidham, Michael S Firstenberg, Erica E Reed, Julie E Mangino, Debra A Goff |
Journal | Pharmacotherapy
(Pharmacotherapy)
Vol. 30
Issue 10
Pg. 1016-20
(Oct 2010)
ISSN: 1875-9114 [Electronic] United States |
PMID | 20874039
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Acids, Carbocyclic
- Cyclopentanes
- Guanidines
- Neuraminidase
- peramivir
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Topics |
- Acids, Carbocyclic
- Adult
- Area Under Curve
- Compassionate Use Trials
- Cyclopentanes
(blood, pharmacokinetics)
- Female
- Guanidines
(blood, pharmacokinetics)
- Half-Life
- Humans
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
(drug therapy)
- Neuraminidase
(antagonists & inhibitors, blood, pharmacokinetics)
- Renal Replacement Therapy
- Young Adult
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