Abstract | AIM: SUBJECTS AND METHODS: The study included 36 patients (24 women and 12 men; mean age 37.56 +/- 0.9 years) with a verified diagnosis of ECO. The height, body weight, waist and hip circumference (WC and HC), and body mass index (BMI) were determined. Adipose tissue content was estimated by a bioimpedance method using an adipose mass analyzer. Serum peptide YY3-36 levels were measured by enzyme immunoassay and blood serotonin concentrations were estimated by high performance liquid chromatography with an electrochemical method. RESULTS: 12-week sibutramine therapy caused a significant reduction in body weight, WC, HC, and BMI (p < 0.05) in all the patients. At the same time they were found to have a considerable body composition change (total body and visceral fat was decreased, total body water increased, and systemic metabolism was lowered). The mean peptide YY3-36 level was significantly decreased. Sibutramine did not affect the serum content of total serotonin in the sera of patients. CONCLUSION:
Sibutramine used in the combined therapy in patients with ECO contributes to an effective and steady-state weight loss. Sibutramine treatment causes a reduction in total neuropeptide YY3-36, systemic metabolism, and adipose tissue at the expense of the visceral depot.
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Authors | Iu Iu Vlasova, A S Ametov |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 82
Issue 8
Pg. 44-7
( 2010)
ISSN: 0040-3660 [Print] Russia (Federation) |
PMID | 20873245
(Publication Type: Clinical Trial, English Abstract, Journal Article)
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Chemical References |
- Appetite Depressants
- Cyclobutanes
- Peptide Fragments
- Peptide YY
- peptide YY (3-36)
- Serotonin
- sibutramine
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Topics |
- Adult
- Anthropometry
- Appetite Depressants
(administration & dosage, therapeutic use)
- Body Composition
(drug effects)
- Body Weight
(drug effects)
- Combined Modality Therapy
- Cyclobutanes
(administration & dosage, therapeutic use)
- Female
- Humans
- Male
- Obesity
(blood, diet therapy, drug therapy, etiology, metabolism)
- Peptide Fragments
- Peptide YY
(blood)
- Serotonin
(blood)
- Treatment Outcome
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