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[Effect of sibutramine (meridia) on body composition, peptide YY3-36 and serotonin levels in patients with exogenous constitutional obesity].

AbstractAIM:
To evaluate the impact of gradual weight loss and the positive effect of sibutramine on metabolic parameters and the levels of serotonin and neuropeptide YY3-36 levels in patients with exogenous constitutional obesity (ECO).
SUBJECTS AND METHODS:
The study included 36 patients (24 women and 12 men; mean age 37.56 +/- 0.9 years) with a verified diagnosis of ECO. The height, body weight, waist and hip circumference (WC and HC), and body mass index (BMI) were determined. Adipose tissue content was estimated by a bioimpedance method using an adipose mass analyzer. Serum peptide YY3-36 levels were measured by enzyme immunoassay and blood serotonin concentrations were estimated by high performance liquid chromatography with an electrochemical method.
RESULTS:
12-week sibutramine therapy caused a significant reduction in body weight, WC, HC, and BMI (p < 0.05) in all the patients. At the same time they were found to have a considerable body composition change (total body and visceral fat was decreased, total body water increased, and systemic metabolism was lowered). The mean peptide YY3-36 level was significantly decreased. Sibutramine did not affect the serum content of total serotonin in the sera of patients.
CONCLUSION:
Sibutramine used in the combined therapy in patients with ECO contributes to an effective and steady-state weight loss. Sibutramine treatment causes a reduction in total neuropeptide YY3-36, systemic metabolism, and adipose tissue at the expense of the visceral depot.
AuthorsIu Iu Vlasova, A S Ametov
JournalTerapevticheskii arkhiv (Ter Arkh) Vol. 82 Issue 8 Pg. 44-7 ( 2010) ISSN: 0040-3660 [Print] Russia (Federation)
PMID20873245 (Publication Type: Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Appetite Depressants
  • Cyclobutanes
  • Peptide Fragments
  • Peptide YY
  • peptide YY (3-36)
  • Serotonin
  • sibutramine
Topics
  • Adult
  • Anthropometry
  • Appetite Depressants (administration & dosage, therapeutic use)
  • Body Composition (drug effects)
  • Body Weight (drug effects)
  • Combined Modality Therapy
  • Cyclobutanes (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Male
  • Obesity (blood, diet therapy, drug therapy, etiology, metabolism)
  • Peptide Fragments
  • Peptide YY (blood)
  • Serotonin (blood)
  • Treatment Outcome

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