Abstract |
The effect of a non- protein fraction from an extract of inflamed skin of rabbits inoculated with vaccinia virus ( Neurotropin, NSP) was studied on Meth A tumor-induced delayed type hypersensitivity (Meth A-DTH) in BALB/c mice. NSP enhanced the Meth A-DTH. NSP also enhanced the DTH suppressed with 5-fluorouracil (5-FU). Moreover, NSP inhibited the fatal effect of 5-FU and restored the decrease of body weight caused by 5-FU. However, NSP reduced partially but significantly the suppression of the tumor growth by 5-FU. NSP may be useful for cancer treatment in combination with chemotherapeutic agents, if NSP does not inhibit their antitumor activity.
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Authors | H Mori, Y Kurimoto, Q A Xu, A Koda |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 54
Issue 4
Pg. 468-72
(Dec 1990)
ISSN: 0021-5198 [Print] Japan |
PMID | 2087010
(Publication Type: Journal Article)
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Chemical References |
- Polysaccharides
- Tissue Extracts
- neurotropin
- Fluorouracil
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Topics |
- Animals
- Fluorouracil
(antagonists & inhibitors, pharmacology)
- Hypersensitivity, Delayed
(chemically induced)
- Mice
- Mice, Inbred BALB C
- Polysaccharides
(pharmacology)
- Rabbits
- Tissue Extracts
(pharmacology)
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