[Oxaliplatin plus capecitabine for advanced gastric cancer: report of 38 cases].

Abstract

OBJECTIVE:

To evaluate the efficacy and toxicity of the combination chemotherapy of oxaliplatin with capecitabine(XELOX)in patients with advanced gastric cancer.

METHODS:

Thirty-eight advanced gastric cancer patients who received XELOX regimen during 2004-2009 were analyzed retrospectively. The combination chemotherapy included oxaliplatin as 2-hour infusion on day 1 and capecitabine po bid on days 1 to 14. Treatment was repeated every 3 weeks.

RESULTS:

XELOX regime was applied as first-line therapy in 34 patients and as second-line therapy in 4 patients. After three cycles of chemotherapy, the outcomes in 32 patients who received XELOX as the first-line therapy included partial response (n = 8,25.0%), stable disease (n=14,43.8%), and progressive disease (n=10, 31.2%); no patient achieved complete response. The median time to progression and overall survival time were 7.0 months (95% CI: 4.5-9.5 months) and 12 months (95% CI: 9.8-14.2 months), respectively. One-year and two-year survival rates were 40.6% and 23.7%, respectively. Grade 3-4 toxicities including neutropenia (10.5%), thrombocytopenia (2.6%), nausea (7.9%), and vomiting (5.3%)were noted in a few patients.

CONCLUSION:

XELOX regimen can be effectively and safely applied as first-line treatment for advanced gastric cancer patients.

• Authors: Mei Guan, Lu Zhang, Lin Zhao, Chun-mei Bai
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 32 Issue 4 Pg. 407-11 (Aug 2010) ISSN: 1000-503X [Print] China
• PMID: 20868599 (Publication Type: Journal Article)

Chemical References

• Organoplatinum Compounds
• Oxaloacetates
• Oxaliplatin
• Deoxycytidine
• Capecitabine
• Fluorouracil

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Capecitabine
• Deoxycytidine (administration & dosage, analogs & derivatives, therapeutic use)
• Female
• Fluorouracil (administration & dosage, analogs & derivatives, therapeutic use)
• Humans
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage)
• Oxaliplatin
• Oxaloacetates
• Retrospective Studies
• Stomach Neoplasms (drug therapy)
• Treatment Outcome