Early cholestasis in neonatal lupus erythematosus.

Abstract

Neonatal lupus erythematosus is an immune-mediated disease caused by transplacental passage of maternal autoantibodies, primarily anti-Ro (SSA) and anti-La (SSB). The major clinical manifestations are congenital heart block, cutaneous lupus lesions, and hematologic problems. Hepatic, pulmonary, and neurological involvements are rare. We report a 5-day-old male neonate, born to a clinically asymptomatic mother, presenting with conjugated hyperbilirubinemia, cutaneous lupus lesions, congenital heart block, and thrombocytopenia. Both the neonate and his mother had high titers of antinuclear antibodies (1:640), anti-Ro (SSA), and anti-La (SSB) antibodies. The thrombocytopenia improved with prednisolone (2 mg/kg/day) for 14 days. The skin lupus rashes and bilirubin resolved 2 months later, and liver enzymes were completely normal by 6 months.

• Authors: Mozhgan Shahian, Amir Khosravi, Mohammad-Hossein Anbardar
• Journal: Annals of Saudi medicine (Ann Saudi Med) 2011 Jan-Feb Vol. 31 Issue 1 Pg. 80-2 ISSN: 0975-4466 [Electronic] Saudi Arabia
• PMID: 20864789 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Glucocorticoids
• Prednisolone

Topics

• Autoantibodies (blood)
• Cholestasis (complications)
• Glucocorticoids (therapeutic use)
• Heart Block (complications, congenital)
• Humans
• Hyperbilirubinemia (complications)
• Infant, Newborn
• Lupus Erythematosus, Cutaneous (complications, diagnosis, immunology)
• Male
• Prednisolone (therapeutic use)
• Serologic Tests
• Thrombocytopenia (complications, drug therapy)