Rizatriptan reduces vestibular-induced motion sickness in migraineurs.

A previous pilot study suggested that rizatriptan reduces motion sickness induced by complex vestibular stimulation. In this double-blind, randomized, placebo-controlled study we measured motion sickness in response to a complex vestibular stimulus following pretreatment with either rizatriptan or a placebo. Subjects included 25 migraineurs with or without migraine-related dizziness (23 females) aged 21-45 years (31.0 ± 7.8 years). Motion sickness was induced by off-vertical axis rotation in darkness, which stimulates both the semicircular canals and otolith organs of the vestibular apparatus. Results indicated that of the 15 subjects who experienced vestibular-induced motion sickness when pretreated with placebo, 13 showed a decrease in motion sickness following pretreatment with rizatriptan as compared to pretreatment with placebo (P < 0.02). This significant effect was not seen when subjects were exposed to more provocative vestibular stimulation. We conclude that the serotonin agonist, rizatriptan, reduces vestibular-induced motion sickness by influencing serotonergic vestibular-autonomic projections.
AuthorsJoseph M Furman, Dawn A Marcus, Carey D Balaban
JournalThe journal of headache and pain (J Headache Pain) Vol. 12 Issue 1 Pg. 81-8 (Feb 2011) ISSN: 1129-2377 [Electronic] Italy
PMID20862509 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Serotonin Receptor Agonists
  • Triazoles
  • Tryptamines
  • rizatriptan
  • Adult
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders (complications, drug therapy)
  • Motion Sickness (drug therapy, etiology)
  • Serotonin Receptor Agonists (administration & dosage, adverse effects)
  • Treatment Outcome
  • Triazoles (administration & dosage, adverse effects)
  • Tryptamines (administration & dosage, adverse effects)
  • Vestibular Diseases (drug therapy, etiology)
  • Young Adult

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