Abstract | AIM: METHODS: RESULTS: The protein expression level of TS was significantly higher (P < 0.05) in the tumor than in the normal tissue, and significantly lower (P < 0.05) in the responders than in the non-responders. We were able to evaluate the correlation between changes in the protein expression levels of TS, DPD and OPRT and chemotherapeutic responses in 7 patients by assessing tumor tissues more than twice. In the responders, the protein expression level of TS was < 40 ng/mg protein. However, there were significant increases in the protein expression levels of TS (P < 0.01) and DPD (P < 0.05) after chemotherapy in 3 patients. In these cases, the patient assessment changed from "responder" to "non-responder". In the non-responders, the protein expression level of TS was > 40 ng/mg protein. CONCLUSION:
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Authors | Ikuko Miyazaki, Takashi Kawai, Youji Harada, Fuminori Moriyasu |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 16
Issue 36
Pg. 4575-82
(Sep 28 2010)
ISSN: 2219-2840 [Electronic] United States |
PMID | 20857529
(Publication Type: Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Drug Combinations
- S 1 (combination)
- Tegafur
- Oxonic Acid
- Dihydrouracil Dehydrogenase (NADP)
- Thymidylate Synthase
- Orotate Phosphoribosyltransferase
- Cisplatin
- Fluorouracil
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Topics |
- Adult
- Aged
- Antimetabolites, Antineoplastic
(therapeutic use)
- Cisplatin
(therapeutic use)
- Dihydrouracil Dehydrogenase (NADP)
(metabolism)
- Drug Combinations
- Female
- Fluorouracil
(metabolism, therapeutic use)
- Humans
- Male
- Middle Aged
- Orotate Phosphoribosyltransferase
(metabolism)
- Oxonic Acid
(therapeutic use)
- Stomach Neoplasms
(blood, drug therapy, enzymology)
- Tegafur
(therapeutic use)
- Thymidylate Synthase
(blood)
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