Abstract | BACKGROUND AND AIM: SUBJECTS AND METHODS: 23 patients with Graves' hyperthyroidism were identified who met the inclusion criteria of at least 24 months follow-up after initiation of methimazole and availability of concurrent measurements of serum TSH and TSI. RESULTS: TSI disappeared in 12 patients (Group A) and persisted in 11 patients (Group B). Initial T4 was not significantly different between the 2 groups. However, TSI was significantly lower in Group A than Group B [median (interquartile range) 179 (152-212)% vs 255 (208-369)%, p=0.0009]. In Group A, TSH normalized during treatment, and this anteceded disappearance of TSI by a significant time interval [median (interquartile range) 6 (3-8) months vs 15 (11-20) months, p=0.005]. In Group B, TSI persisted in all patients during follow-up ranging from 24 to 73 months. No correlation was found to exist between serum TSH and TSI, and for Group B TSI at final follow-up was not significantly different from the initial value [median (interquartile range) 255 (208-369)% vs 236 (160-310)%, p=0.4]. CONCLUSIONS: These findings do not support the suggestion that TSI has a direct suppressive effect on TSH secretion.
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Authors | K A Woeber |
Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
Vol. 34
Issue 3
Pg. 222-4
(Mar 2011)
ISSN: 1720-8386 [Electronic] Italy |
PMID | 20855936
(Publication Type: Journal Article)
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Chemical References |
- Immunoglobulins, Thyroid-Stimulating
- Thyrotropin
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Topics |
- Animals
- CHO Cells
- Cricetinae
- Cricetulus
- Graves Disease
(blood, immunology)
- Humans
- Immunoglobulins, Thyroid-Stimulating
(blood)
- Thyrotropin
(blood)
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