Hexaminolevulinate guided fluorescence cystoscopy reduces recurrence in patients with nonmuscle invasive bladder cancer.

Abstract

PURPOSE:

We assessed the impact that improved detection of nonmuscle invasive bladder cancer with hexaminolevulinate fluorescence cystoscopy may have on early recurrence rates.

MATERIALS AND METHODS:

This prospective, randomized study enrolled 814 patients suspected of having bladder cancer at increased risk for recurrence. All patients underwent white light cystoscopy and mapping of lesions, followed by transurethral resection of the bladder when indicated. Patients in the fluorescence group also received intravesical hexaminolevulinate solution at least 1 hour before cystoscopy to induce fluorescence of cancerous lesions, and underwent additional inspection with blue light before and after transurethral resection of the bladder. Adjuvant intravesical therapy was based on risk. Followup cystoscopy at 3, 6 and 9 months was conducted with white light.

RESULTS:

Detection was performed as a within patient comparison in the fluorescence group. In this group 286 patients had at least 1 Ta or T1 tumor (intent to treat). In 47 patients (16%) at least 1 of the tumors was seen only with fluorescence (p = 0.001). During the 9-month followup (intent to treat) there was tumor recurrence in 128 of 271 patients (47%) in the fluorescence group and 157 of 280 (56%) in the white light group (p = 0.026). The relative reduction in recurrence rate was 16%.

CONCLUSIONS:

Hexaminolevulinate fluorescence cystoscopy significantly improves the detection of Ta and T1 lesions and significantly reduces the rate of tumor recurrence at 9 months.

• Authors: Arnulf Stenzl, Maximilian Burger, Yves Fradet, Lance A Mynderse, Mark S Soloway, J Alfred Witjes, Martin Kriegmair, Alexander Karl, Yu Shen, H Barton Grossman
• Journal: The Journal of urology (J Urol) Vol. 184 Issue 5 Pg. 1907-13 (Nov 2010) ISSN: 1527-3792 [Electronic] United States
• PMID: 20850152 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Carbon Radioisotopes
• Aminolevulinic Acid
• 5-aminolevulinic acid hexyl ester

Topics

• Aged
• Aminolevulinic Acid (analogs & derivatives)
• Carbon Radioisotopes
• Cystoscopy (methods)
• Female
• Fluorescence
• Humans
• Male
• Neoplasm Recurrence, Local (prevention & control)
• Prospective Studies
• Urinary Bladder Neoplasms (diagnosis, surgery)