[Use of atracurium for the prevention of fasciculations and succinylcholine myalgia in athletes undergoing orthopedic surgery].

The Authors report their clinical experience about the use of atracurium besylate in preventing succinylcholine-induced fasciculations and postoperative myalgias in fifty athletes (ASA class 1), submitted to arthroscopic meniscectomy. The patients were pretreated with atracurium 5 mg i.v. or saline solution in a double-blind fashion. After 2.5 minutes, succinylcholine 1.3 mg/kg was administered, and fasciculations were recorded on a scale ranging from 0 to 3. Twenty-four hours after surgery all subjects were questioned about myalgias occurrence, scored by a 0-3 scale. Fasciculations occurred in all patients who received saline and in 44% of those treated with atracurium. Myalgias on the postoperative day were observed in 80% of patients treated with saline solution, but only in 36% of patients who received atracurium. The difference between atracurium and saline solution was statistically significant (p less than 0.001) either for fasciculations or myalgias incidence. These findings show that atracurium 5 mg i.v. is effective in preventing succinylcholine-induced fasciculations and postoperative myalgias, and suggest atracurium as the drug of choice for this purpose, particularly in muscular subjects.
AuthorsI Pagani, F Ramaioli, F Albertario, R Mora, R V Dionigi
JournalMinerva anestesiologica (Minerva Anestesiol) Vol. 56 Issue 11 Pg. 1413-7 (Nov 1990) ISSN: 0375-9393 [Print] Italy
Vernacular TitleImpiego dell'atracurium nella prevenzione delle fascicolazioni e delle mialgie da succinilcolina in atleti sottoposti a chirurgia ortopedica.
PMID2084590 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Review)
Chemical References
  • Atracurium
  • Succinylcholine
  • Adolescent
  • Adult
  • Atracurium (therapeutic use)
  • Fasciculation (chemically induced, prevention & control)
  • Female
  • Humans
  • Male
  • Muscular Diseases (chemically induced, prevention & control)
  • Orthopedics
  • Pain (chemically induced, prevention & control)
  • Postoperative Complications (chemically induced, prevention & control)
  • Premedication
  • Sports
  • Succinylcholine (adverse effects)

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