Abstract | PURPOSE: METHODS: Twenty-five eyes of 24 patients with corneal infiltrates (bacterial or fungal) were treated with appropriate anti-infective agents along with bromfenac twice daily for up to 102 days to treat the pain caused by the infection. Follow-up visits were frequent in the first 2 weeks upon initiation of treatment, then at least weekly until infections were resolved. The best corrected visual acuity, location, size, and density of corneal infiltrates, the size and presence of a corneal epithelial defect, subjective eye pain (scale of 0-4) and time to pain resolution, the ability to conduct daily activities, and adverse events were recorded at each follow-up visit. The results of these treated patients were compared with those of 10 control eyes with corneal infiltrates (bacterial or fungal) where appropriate anti-infectives were used without adjunct medications. RESULTS: Fifty-two percent of bromfenac-treated patients reported no pain by day 3, compared with 0% of untreated controls (P=0.023). Most of the treated patients' epithelium healed by day 20 (68%) compared with only 10% of controls (P=0.040). Most bromfenac-treated patients (71%) returned to normal activities within 2 days of starting treatment with bromfenac, compared with 0% of controls (P=0.018). No adverse events were recorded. CONCLUSION:
Bromfenac was effective in treating pain associated with infectious keratitis and did not delay corneal epithelialization nor cause any corneal adverse events in this group of 25 eyes.
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Authors | Barry A Schechter, William Trattler |
Journal | Advances in therapy
(Adv Ther)
Vol. 27
Issue 10
Pg. 756-61
(Oct 2010)
ISSN: 1865-8652 [Electronic] United States |
PMID | 20845001
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Infective Agents, Local
- Anti-Inflammatory Agents, Non-Steroidal
- Benzophenones
- Bromobenzenes
- Ophthalmic Solutions
- bromfenac
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Infective Agents, Local
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects, therapeutic use)
- Benzophenones
(administration & dosage, adverse effects, therapeutic use)
- Bromobenzenes
(administration & dosage, adverse effects, therapeutic use)
- Corneal Ulcer
(complications)
- Female
- Humans
- Male
- Middle Aged
- Ophthalmic Solutions
- Pain
(drug therapy, etiology)
- Prospective Studies
- Young Adult
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