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[Omalizumab for therapy-resistant chronic urticaria with angioedema].

Abstract
A 29-old man presented with severe chronic urticaria and angioedema. Routine evaluation including history, laboratory parameters and imaging procedures did not reveal any pathologic findings. We tried combined therapy regimes including high-dose systemic corticosteroids and antihistamines, leukotriene antagonist, cyclosporine and antibiotics. Because of a poor response and dramatic escalation of symptoms, we initiated therapy with omalizumab resulting in the complete remission of the chronic urticaria after two weeks.
AuthorsH Korkmaz, S Eigelshoven, B Homey
JournalDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 61 Issue 10 Pg. 828-31 (Oct 2010) ISSN: 1432-1173 [Electronic] Germany
Vernacular TitleOmalizumab bei therapierefraktärer chronischer Urtikaria mit Angioödem.
PMID20842328 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Anti-Allergic Agents
  • Anti-Inflammatory Agents
  • Antibodies, Anti-Idiotypic
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Histamine H1 Antagonists, Non-Sedating
  • Omalizumab
  • Immunoglobulin E
  • Loratadine
  • Prednisolone
  • desloratadine
Topics
  • Adult
  • Angioedema (drug therapy, immunology)
  • Anti-Allergic Agents (therapeutic use)
  • Anti-Inflammatory Agents (therapeutic use)
  • Antibodies, Anti-Idiotypic
  • Antibodies, Monoclonal (therapeutic use)
  • Antibodies, Monoclonal, Humanized
  • Chronic Disease
  • Dose-Response Relationship, Drug
  • Drug Resistance
  • Drug Therapy, Combination
  • Histamine H1 Antagonists, Non-Sedating (therapeutic use)
  • Humans
  • Immunoglobulin E (blood)
  • Leukocytosis (drug therapy, immunology)
  • Loratadine (analogs & derivatives, therapeutic use)
  • Male
  • Omalizumab
  • Prednisolone (therapeutic use)

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