Abstract | BACKGROUND: METHODS: A longitudinal study was performed on a cohort of HIV-infected patients with chronic hepatitis B or C who were followed since 2004 at Hospital Carlos III (Madrid, Spain) with periodic TE assessments. The primary outcome was the development of cirrhosis, defined as liver stiffness >12.5 KPa. RESULTS: A total of 508 HIV-infected patients were examined, of whom 54 developed liver cirrhosis during a mean ±(SD) follow-up of 2.6 ±1.0 years (overall incidence was 41.13 cases per 1,000 person-years). The risk of developing cirrhosis was significantly higher in 297 HCV- RNA-positive patients (either untreated or non-responders to hepatitis C therapy) compared with 55 patients who had cleared HCV with therapy (odds ratio 3.73, 95% confidence interval 1.06-13.17; P=0.04). By contrast, the risk of developing cirrhosis was low and similar in 24 HIV-HBV-coinfected patients under long-term suppressive HBV therapy (mainly tenofovir disoproxil fumarate), 132 HIV-infected patients without chronic liver disease and those who had cleared HCV with therapy. CONCLUSIONS:
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Authors | Paula Tuma, Jose Medrano, Salvador Resino, Eugenia Vispo, Antonio Madejón, Carlos Sánchez-Piedra, Pablo Rivas, Pablo Labarga, Luz Martín-Carbonero, Pablo Barreiro, Vincent Soriano |
Journal | Antiviral therapy
(Antivir Ther)
Vol. 15
Issue 6
Pg. 881-6
( 2010)
ISSN: 2040-2058 [Electronic] England |
PMID | 20834100
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Antiretroviral Therapy, Highly Active
(adverse effects)
- Female
- HIV Infections
(complications, drug therapy)
- Hepatitis B, Chronic
(complications, epidemiology)
- Hepatitis C, Chronic
(complications, epidemiology)
- Humans
- Incidence
- Liver Cirrhosis
(epidemiology, etiology)
- Longitudinal Studies
- Male
- Middle Aged
- Spain
- Treatment Outcome
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