Abstract | BACKGROUND:
Malignant hyperthermia is a potentially lethal inherited hypermetabolic syndrome that develops in susceptible individuals following administration of depolarising neuromuscular relaxants or volatile anaesthetics. Genetic analysis can only confirm a diagnosis of malignant hyperthermia in about 70%, and in the remainder an in-vitro contracture test, with halothane and caffeine, on muscle obtained from open muscle biopsy is required to establish the diagnosis. As the licence for clinical use of halothane expired in 2005, its continuing availability is in doubt. More modern volatile anaesthetics such as enflurane, isoflurane, desflurane and sevoflurane are less potent triggers of malignant hyperthermia in humans and pigs. The aim of this study was to investigate whether these agents can be considered possible substitutes for halothane in a modified in-vitro contracture test. METHOD: RESULTS: CONCLUSION:
Halothane was the strongest discriminator for malignant hyperthermia in the in-vitro contracture tests. It remains the ideal substance for diagnostic testing and cannot simply be replaced by other agents in this test.
|
Authors | Thomas Metterlein, Frank Schuster, Peter Kranke, Norbert Roewer, Martin Anetseder |
Journal | European journal of anaesthesiology
(Eur J Anaesthesiol)
Vol. 28
Issue 4
Pg. 251-5
(Apr 2011)
ISSN: 1365-2346 [Electronic] England |
PMID | 20827211
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Anesthetics, Inhalation
- Methyl Ethers
- Sevoflurane
- Enflurane
- Desflurane
- Isoflurane
- Halothane
|
Topics |
- Anesthetics, Inhalation
- Biopsy
- Case-Control Studies
- Desflurane
- Dose-Response Relationship, Drug
- Enflurane
- Halothane
- Humans
- Isoflurane
(analogs & derivatives)
- Malignant Hyperthermia
(diagnosis, etiology, physiopathology)
- Methyl Ethers
- Muscle Contraction
(drug effects)
- Muscle, Skeletal
(drug effects, physiopathology)
- Predictive Value of Tests
- Sevoflurane
|