HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison of intravenous ketorolac tromethamine and morphine sulfate in the treatment of postoperative pain.

Abstract
This study compared the efficacy and safety of ketorolac tromethamine and morphine sulfate in alleviating moderate or severe pain immediately after major surgery. One hundred twenty-two patients were randomly assigned to receive single intravenous injections of ketorolac 10 mg, ketorolac 30 mg, morphine 2 mg, or morphine 4 mg; patients could receive a second dose 15 minutes thereafter, upon request, and most received both available doses. Analgesic efficacy was measured by interviewing patients and assessing pain intensity and pain relief for 6 hours after the first medication administration. The two drugs showed a similar onset of action, peaking 1 hour after administration. When placed in order of descending efficacy, the mean scores for most efficacy measures fell into the following sequence: ketorolac 30 mg, ketorolac 10 mg, morphine 4 mg, and morphine 2 mg. There were no statistically significant differences among the two ketorolac doses and the high dose of morphine, but all three of these treatments were significantly superior to the low morphine dose. One patient who took morphine 4 mg withdrew because of drowsiness; other common adverse events reported included nausea, vomiting, somnolence, and dyspepsia. There were no statistically significant differences in the frequency of adverse events among the treatment groups. Intravenous ketorolac is effective for the treatment of postoperative pain.
AuthorsC R Brown, J E Moodie, V M Wild, L J Bynum
JournalPharmacotherapy (Pharmacotherapy) Vol. 10 Issue 6 ( Pt 2) Pg. 116S-121S ( 1990) ISSN: 0277-0008 [Print] United States
PMID2082307 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Drug Combinations
  • Tromethamine
  • Ketorolac Tromethamine
  • Morphine
  • Tolmetin
Topics
  • Adolescent
  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects, therapeutic use)
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Injections, Intravenous
  • Ketorolac Tromethamine
  • Male
  • Middle Aged
  • Morphine (administration & dosage, adverse effects, therapeutic use)
  • Pain, Postoperative (drug therapy)
  • Time Factors
  • Tolmetin (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
  • Tromethamine (administration & dosage, adverse effects, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: