[Chronic neutrophilic leukemia: apropos of 2 cases and review of the literature].

Abstract

Two patients with chronic neutrophilic leukemia, a rare myeloproliferative syndrome, are reported with a review of the literature. The major features of the 34 collected cases (including the two patients reported here) were persistent leukocytosis simulating a leukemoid reaction, hepatosplenomegaly, hyperuricemia, increased vitamin B12 blood level, increased leukocyte alkaline phosphatase and absence of the Philadelphia chromosome. Infection was the leading cause of death. Concomitant multiple myeloma was found in eight patients.

• Authors: C Hidalgo, J Camacho, J Fernández, A Hernández, F Poveda, J M Peña
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 95 Issue 11 Pg. 421-3 (Oct 06 1990) ISSN: 0025-7753 [Print] Spain
• Vernacular Title: Leucemia neutrofílica crónica: a propósito de dos casos y revisión de la literatura.
• PMID: 2082113 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Diagnosis, Differential
• Female
• Humans
• Leukemia, Neutrophilic, Chronic (complications, diagnosis, mortality)
• Leukemoid Reaction (diagnosis)
• Male
• Middle Aged
• Multiple Myeloma (complications)