[Prostanoids in the treatment of pulmonary arterial hypertension].

Abstract

Prostacyclin, endothelin-1, and nitric oxide pathways are involved in the pathogenesis of pulmonary arterial hypertension. This devastating disease of the pulmonary vasculature is associated with vasoconstriction, thrombosis and proliferation, and this may be partly due to lack of endogenous prostacyclin secondary to prostacyclin synthase downregulation. Prostanoids (prostacycin analogues) are potent vasodilators and possess antiaggregant, antiinflammatory and antiproliferative properties. The first agent to be approved for the treatment of pulmonary arterial hypertension was epoprostenol. In the last decade other prostanoids (treprostinil, iloprost) has been approved for the treatment of pulmonary arterial hypertension.

• Authors: Murat Başkurt, M Serdar Küçükoğlu
• Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology (Anadolu Kardiyol Derg) Vol. 10 Suppl 2 Pg. 2-8 (Sep 2010) ISSN: 1308-0032 [Electronic] Turkey
• Vernacular Title: Pulmoner arteriyel hipertansiyon tedavisinde prostanoidler.
• PMID: 20819749 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Prostaglandins
• Prostaglandins, Synthetic
• Vasodilator Agents

Topics

• Hemodynamics (drug effects)
• Humans
• Hypertension, Pulmonary (drug therapy)
• Prostaglandins (therapeutic use)
• Prostaglandins, Synthetic (therapeutic use)
• Treatment Outcome
• Vasodilator Agents (therapeutic use)