Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size.

Abstract

This study was designed to investigate the expression of four actin-binding proteins, alpha-actinin-4, cofilin 1, fascin and elongation factor 1-alpha 2 (eEF1A2), in samples of breast cancer from 112 patients with different stages of breast cancer (stages T0 - T1, T2 and T3) compared with normal control tissues (n = 33). Levels of eEF1A2 and alpha-actinin-4 mRNA appeared to be unrelated to tumour size, except for a significant down-regulation of alpha-actinin-4 mRNA in T3 cases. Significant up-regulation of cofilin 1 mRNA was associated with stages T0 - T1 and T2; up-regulation seen at stage T3 was not significant compared with control tissue. Fascin mRNA levels were significantly reduced at all three tumour stages (T0 - T1, T2 and T3) compared with control tissue. In conclusion, some components of the actin cytoskeletal system might hold significant potential as targets in future cancer therapies.

• Authors: Y Zhang, X Tong
• Journal: The Journal of international medical research (J Int Med Res) 2010 May-Jun Vol. 38 Issue 3 Pg. 1042-8 ISSN: 0300-0605 [Print] England
• PMID: 20819441 (Publication Type: Journal Article)

Chemical References

• ACTN4 protein, human
• CFL1 protein, human
• Carrier Proteins
• Cofilin 1
• EEF1A2 protein, human
• FSCN1 protein, human
• Microfilament Proteins
• Peptide Elongation Factor 1
• RNA, Messenger
• Actinin

Topics

• Actinin (genetics, metabolism)
• Adenocarcinoma (genetics, metabolism, secondary)
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Breast (metabolism, pathology)
• Breast Neoplasms (genetics, metabolism, pathology)
• Carrier Proteins (genetics, metabolism)
• Cofilin 1 (genetics, metabolism)
• Female
• Fibroadenoma (genetics, metabolism, pathology)
• Gene Expression
• Humans
• Mastectomy
• Microfilament Proteins (genetics, metabolism)
• Middle Aged
• Peptide Elongation Factor 1 (genetics, metabolism)
• RNA, Messenger (metabolism)
• Young Adult