Vitamin D metabolites in spasmophilia.

Abstract

The comparison of 20 untreated spasmophilic patients (2 men, 18 women) with 25 healthy subjects revealed no significant differences in vitamin D metabolite plasma levels or in other laboratory indexes of calcium metabolism except for ionized and cytosolic free calcium levels which were lower in the former group (P less than 0.01; P less than 0.001). After 3 months treatment with calcitonin and 25-hydroxyvitamin D there was a clear improvement in patient symptoms, no significant modification of 1,25-dihydroxyvitamin D levels and significant increases in 25-hydroxyvitamin D, cytosolic free calcium and urinary calcium (P less than 0.001, P less than 0.001 and P less than 0.01, respectively). We conclude that high plasma levels of 25-hydroxyvitamin D play an important role in restoring normal cytosolic free calcium levels and reducing clinical manifestations in spasmophilia.

• Authors: M P Caraceni, G G Gandolini, F Campanini, M A Iannetta, S Ortolani
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 44 Issue 9 Pg. 479-82 ( 1990) ISSN: 0753-3322 [Print] France
• PMID: 2081276 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Vitamin D
• Calcitonin
• Calcifediol
• Calcium

Topics

• Adult
• Aged
• Calcifediol (blood, therapeutic use)
• Calcitonin (therapeutic use)
• Calcium (blood, urine)
• Female
• Humans
• Male
• Middle Aged
• Tetany (drug therapy, metabolism)
• Vitamin D (metabolism)