Metabolic activity of the subthalamic nucleus in a primate model of L-dopa-unresponsive parkinsonism.

Abstract

Increased activity of the subthalamic nucleus (STN) is critical in mediating motor symptoms of Parkinson's disease. To determine if altered STN activity also occurs in levodopa (L-Dopa)-unresponsive parkinsonism due to a combined nigral and striatal degeneration, metabolic activity of the STN was assessed using cytochrome oxidase (CO) histochemistry in monkeys with nigral, striatal, or nigral+striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and/or 3-nitropropionic acid (3NP). MPTP- and MPTP+3NP-treated monkeys had a similar parkinsonian score and were clinically indistinguishable. However, CO activity in the STN was significantly increased in MPTP-induced parkinsonism but not in MPTP+3NP-induced striatonigral degeneration. These results indicate that metabolic activity of the STN is normal following a combined nigral+striatal degeneration and may help to understand the lack of effect of STN stimulation in L-Dopa-unresponsive parkinsonism.

• Authors: Pierre-Olivier Fernagut, Quentin Barraud, Erwan Bezard, Imad Ghorayeb, Francois Tison
• Journal: Neurological research (Neurol Res) Vol. 32 Issue 10 Pg. 1050-3 (Dec 2010) ISSN: 1743-1328 [Electronic] England
• PMID: 20810027 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Levodopa

Topics

• Animals
• Corpus Striatum (drug effects, pathology, physiopathology)
• Disease Models, Animal
• Energy Metabolism (physiology)
• Female
• Levodopa (administration & dosage)
• Macaca fascicularis
• Parkinsonian Disorders (metabolism, physiopathology)
• Substantia Nigra (drug effects, pathology, physiopathology)
• Subthalamic Nucleus (drug effects, metabolism, physiopathology)