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Ichthyosiform sarcoidosis: A case report and review of the literature.

Abstract
Sarcoidosis is a potentially life-threatening, multisystem, granulomatous disease that can present with cutaneous manifestations in patients. A rare cutaneous manifestation of this disease may resemble acquired ichthyosis. We report a 45-year-old woman with a several year history of dyspnea on exertion and panuveitis who presented to a county hospital with acquired lower extremity ichthyosis and a biopsy consistent with both acquired ichthyosis and noncaseating, granulomatous sarcoidosis. To our knowledge, this entity has been described in only 22 previous independent cases, with the present case being 1 of only 5 cases to rapidly progress to full systemic involvement. Furthermore, it is important to recognize the manifestations of sarcoidosis in the skin, because these may be the presenting signs of systemic illness.
AuthorsBrian P Kelley, Dornechia E George, Todd M LeLeux, Sylvia Hsu
JournalDermatology online journal (Dermatol Online J) Vol. 16 Issue 8 Pg. 5 (Aug 15 2010) ISSN: 1087-2108 [Electronic] United States
PMID20804682 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Antibodies, Antinuclear
  • Dermatologic Agents
  • Parathyroid Hormone
  • Peptidyl-Dipeptidase A
  • Prednisone
Topics
  • Antibodies, Antinuclear (blood)
  • Biopsy
  • Dermatologic Agents (therapeutic use)
  • Female
  • Granuloma (diagnosis, drug therapy)
  • Humans
  • Hypercalcemia (diagnosis)
  • Ichthyosis (diagnosis, drug therapy, pathology)
  • Middle Aged
  • Panuveitis (drug therapy, pathology)
  • Parakeratosis (diagnosis, drug therapy)
  • Parathyroid Hormone (blood)
  • Peptidyl-Dipeptidase A (blood)
  • Prednisone (therapeutic use)
  • Radiography
  • Sarcoidosis (diagnostic imaging, drug therapy, pathology)
  • Treatment Outcome

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