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Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia.

AbstractOBJECTIVE:
To determine the mean arterial pressure (MAP) and middle cerebral artery mean blood flow velocity (MFV) responses to 5 and 10mg midodrine during head-up tilt (HUT) in persons with tetraplegia.
DESIGN:
Prospective dose-response trial.
SETTING:
James J. Peters Veterans Administration Medical Center.
PARTICIPANTS:
Persons (N=10) with chronic tetraplegia (duration of injury=23+/-11 y).
INTERVENTION:
A dose titration study was performed over 3 testing days: control (no drug), 5mg midodrine (5mg), or 10mg midodrine (10mg) during 30 minutes of baseline (predrug/no drug), 30 minutes of supine rest postdrug/no drug, 15 minutes of progressive HUT (5 minutes at 15 degrees , 25 degrees , 35 degrees ), and 45 minutes of 45 degrees HUT.
MAIN OUTCOME MEASURES:
MAP and MFV response to midodrine supine and during HUT.
RESULTS:
Ten milligrams of midodrine significantly increased MAP while supine and during the HUT maneuver. Of note, the mean increase in MAP during HUT with 10mg was a result of a robust effect in 2 persons, with minimal change in the remaining 8 study subjects. The reduction in cerebral MFV during HUT was attenuated with 10mg.
CONCLUSIONS:
These findings suggest that midodrine 10mg may be efficacious for treatment of hypotension and orthostatic hypotension in select persons with tetraplegia. Although midodrine is routinely prescribed to treat orthostatic hypotension, the results of our work suggests limited efficacy of this agent, but additional studies in a larger sample of subjects with spinal cord injury should be performed.
AuthorsJill M Wecht, Dwindally Rosado-Rivera, John P Handrakis, Miroslav Radulovic, William A Bauman
JournalArchives of physical medicine and rehabilitation (Arch Phys Med Rehabil) Vol. 91 Issue 9 Pg. 1429-35 (Sep 2010) ISSN: 1532-821X [Electronic] United States
PMID20801263 (Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Vasoconstrictor Agents
  • Midodrine
Topics
  • Adult
  • Cerebrovascular Circulation (drug effects)
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Hypotension (drug therapy, etiology)
  • Hypotension, Orthostatic (drug therapy, etiology)
  • Male
  • Middle Aged
  • Midodrine (pharmacology, therapeutic use)
  • Quadriplegia (complications, rehabilitation)
  • Spinal Cord Injuries (complications, rehabilitation)
  • Tilt-Table Test
  • Vasoconstrictor Agents (pharmacology, therapeutic use)

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