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Efficacy of long-term fluoxetine treatment of obsessive-compulsive disorder.

Abstract
Ten outpatients meeting DSM-III-R criteria for obsessive-compulsive disorder completed a 32-week, open-label study with fluoxetine, a selective serotonin reuptake blocker. The patients were evaluated every four weeks for obsessive-compulsive symptomatology, anxiety, and depression. Significant improvement of obsessive-compulsive and anxiety measures were observed after four weeks, with maximal improvement at eight weeks. Depressed and nondepressed patients showed similar rates of improvement in obsessive-compulsive symptomatology. Overall, fluoxetine was tolerated well by all patients, and no serious side effects were observed. This study suggests that fluoxetine is an effective and safe treatment for obsessive-compulsive disorder, both for short-term alleviation and for long-term maintenance.
AuthorsA Frenkel, J Rosenthal, A Nezu, A Winston
JournalThe Mount Sinai journal of medicine, New York (Mt Sinai J Med) Vol. 57 Issue 6 Pg. 348-52 (Nov 1990) ISSN: 0027-2507 [Print] United States
PMID2079952 (Publication Type: Journal Article)
Chemical References
  • Fluoxetine
Topics
  • Body Weight
  • Female
  • Fluoxetine (administration & dosage, therapeutic use)
  • Humans
  • Male
  • Obsessive-Compulsive Disorder (drug therapy)
  • Time Factors

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