Abstract | OBJECTIVE: DESIGN AND SETTING: This study was conducted at the Nephrological Clinic of L. Pasteur Faculty Hospital and of Medical School of P. J. Safarik University. A combination of 29 marathon runners, 15 patients with CG and NS, 11 patients with AIP, 1 patient with variegate porphyria, 15 healthy subjects, 27 CKD stage 3-4 patients, 30 HD, and 27 CAPD patients were used in the study. RESULTS: After a marathon run, plasma and erythrocyte VB(6) significantly decreased and plasma OA increased. Plasma (15.5 +/- 3.8 nmol/L) and erythrocyte VB(6) (effect of PLP: 42.1% +/- 7.5%) were decreased and plasma OA (9.8 +/- 2.3 micromol/L) was significantly elevated in patients with CGNS and stage 1 CKD. In patients with AIP, deficiency of plasma (24.3 +/- 5.2 nmol/L) and erythrocyte VB(6) (effect of PLP: 46.2% +/- 7.0%) and hyperoxalemia (9.39 +/- 2.5 micromol/L) were present. The urinary excretion of VB(6) and of OA during maximal water diuresis and after intravenous administration of furosemide increased significantly (P < .01), but was not affected by the high intake of NaCl (P > .05). Erythropoietin treatment in HD patients led to the erythrocyte VB(6) deficiency. This finding is an indirect evidence that erythrocyte VB(6) is consumed by the hemoglobin synthesis much more during EPO treatment. In CAPD patients, plasma value of VB(6) (127.3 +/- 66.9 micromol/L) was in the normal range and plasma OA (23.6 +/- 7.4 micromol/L) was significantly elevated. Mean value of peritoneal clearance of VB(6) was 8.8% and of OA was 76.9% of urea clearance. CONCLUSION: Our study indicates that deficiency of VB(6) led to hyperoxalemia and hyperoxaluria in patients with CKD. Deficiency of VB(6) in CKD stage 4-5 patients potentiates the uremic hyperoxalemia and hyperoxaluria.
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Authors | Miroslav Mydlík, Katarína Derzsiová |
Journal | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
(J Ren Nutr)
Vol. 20
Issue 5 Suppl
Pg. S95-102
(Sep 2010)
ISSN: 1532-8503 [Electronic] United States |
PMID | 20797580
(Publication Type: Journal Article)
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Copyright | Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Dialysis Solutions
- Vitamin B 6
- Oxalic Acid
|
Topics |
- Adult
- Dialysis Solutions
(analysis)
- Erythrocytes
(chemistry)
- Female
- Glomerulonephritis
(blood, metabolism, urine)
- Humans
- Kidney Diseases
(blood, metabolism, urine)
- Male
- Nephrotic Syndrome
(blood, metabolism, urine)
- Oxalic Acid
(analysis, blood, urine)
- Peritoneal Dialysis, Continuous Ambulatory
- Porphyria, Acute Intermittent
(blood, metabolism, urine)
- Renal Dialysis
- Running
(physiology)
- Vitamin B 6
(analysis, blood, urine)
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