Abstract | BACKGROUND: There is still lack of special prognostic factor on lung cancer, this study will explore the prognostic value of serum VEGF-C level and lymphangiogenesis of primary cancer and mediastinal lymph nodes in the patients with lung cancer. METHODS: Thirty patients with NSCLC would accept operation (new group) and 30 cases followed up three years postoperative (history group) were chosen respectively. The serum VEGF-C level of new group was tested. The VEGF-C and LYVE-1 expression in the mediastinal lymph nodes were put in practice between two groups. The relationship was analyzed for the serum VEGF-C level, VEGF-C and LYVE-1 expression of primary cancer and mediastinal lymph nodes, mediastinal lymph nodes metastasis and the 3-year survival rate of the patients. RESULTS: (1)In new group, the serum VEGF-C level of N2 patients was significantly higher than that of non-N2 patients. (2)In new group, the serum VEGF-C level was closely correlated with VEGF-C expression of primary cancer. (3)In two groups, the primary cancer and mediastinal metastasis lymph nodes had high VEGF-C expression. (4)VEGF-C expression of primary cancer and mediastinal lymph nodes was closely correlated with LYVE-1 expression between the two groups. (5)VEGF-C and LYVE-1 expression of N2 patients was significantly higher than that of non-N2 patients between two groups. (6)The patients' 3-year-survival rate was closely correlated with VEGF-C expression of primary cancer and mediastinal lymph nodes metastasis. CONCLUSIONS:
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Authors | Yang Shen-Tu, Tiancheng Zhao, Zhengping Ding, Yunzhong Zhou |
Journal | Zhongguo fei ai za zhi = Chinese journal of lung cancer
(Zhongguo Fei Ai Za Zhi)
Vol. 11
Issue 6
Pg. 769-74
(Dec 20 2008)
ISSN: 1999-6187 [Electronic] China |
PMID | 20797326
(Publication Type: English Abstract, Journal Article)
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