Growth hormone deficiency of hypothalamic origin in septo-optic dysplasia.

Abstract

Hypothalamic pituitary function and growth hormone releasing hormone (GHRH) loading tests in two children with septo-optic dysplasia (SOD) revealed isolated GH deficiency in one and deficiencies of growth hormone, adrenocorticotropic hormone and antidiuretic hormone in the other. Secretion of GH was elicited in the first patient by single i.v. bolus administration of GHRH and after repetitive i.v. infusions of GHRH in the second. With these results we confirmed that the hypopituitarism in our patients with SOD was of hypothalamic origin. Both patients also had infantile spasms.

• Authors: S Yukizane, Y Kimura, Y Yamashita, T Matsuishi, H Horikawa, H Ando, F Yamashita
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 150 Issue 1 Pg. 30-3 (Nov 1990) ISSN: 0340-6199 [Print] Germany
• PMID: 2079074 (Publication Type: Journal Article)

Chemical References

• Growth Hormone
• Growth Hormone-Releasing Hormone

Topics

• Adrenal Glands (physiology)
• Brain (abnormalities)
• Child, Preschool
• Female
• Growth Hormone (deficiency)
• Growth Hormone-Releasing Hormone (physiology)
• Humans
• Hypopituitarism (etiology, physiopathology)
• Hypothalamus (physiopathology)
• Infant
• Male
• Optic Nerve (abnormalities)
• Thyroid Gland (physiology)