Abstract | BACKGROUND:
Cardiovascular disease (CVD) is a leading cause of death in the US and Western Europe, but regular use of preventive low-dose aspirin has proven effective in preventing CVD events. The purpose of this study was to explore the potential economic impact in the US if preventive aspirin usage were to be increased in line with clinical guidelines for primary and secondary prevention. METHODS: The risk profile of the US population was characterized using NHANES data, and Framingham cardiovascular risk equations were applied to calculate risk for myocardial infarction, angina and ischemic stroke according to age and gender. Primary and secondary patients were considered separately. Using publicly available unit costs, a budget impact model calculated the annual impact of increased preventive aspirin usage considering gastrointestinal bleeding and hemorrhagic stroke adverse events and diminishing aspirin adherence over a 10-year time horizon. RESULTS: CONCLUSIONS: This budgetary model suggests that there is a strong economic case, both for payers and society, to encourage aspirin use for patients at appropriate risk and per clinical guidelines. It also provides an example of how minimizing costs do not necessarily have to imply a rationing of care. Limitations include the exclusion of other CVD interventions in the analysis.
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Authors | Stephanie C Manson, Agnes Benedict, Feng Pan, Kim U Wittrup-Jensen, A Mark Fendrick |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 26
Issue 10
Pg. 2365-73
(Oct 2010)
ISSN: 1473-4877 [Electronic] England |
PMID | 20738228
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aspirin
(administration & dosage, adverse effects, economics)
- Cardiovascular Diseases
(economics, epidemiology, prevention & control)
- Chemoprevention
(economics, statistics & numerical data)
- Cost Savings
(statistics & numerical data)
- Cost-Benefit Analysis
- Dose-Response Relationship, Drug
- Female
- Gastrointestinal Hemorrhage
(chemically induced, economics, epidemiology)
- Guidelines as Topic
- Humans
- Male
- Middle Aged
- Models, Economic
- Patient Compliance
(statistics & numerical data)
- Primary Prevention
(economics)
- United States
(epidemiology)
- Young Adult
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