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Animal models.

Abstract
As clinical studies reveal that chemotherapeutic agents may impair several different cognitive domains in humans, the development of preclinical animal models is critical to assess the degree of chemotherapy-induced learning and memory deficits and to understand the underlying neural mechanisms. In this chapter, the effects of various cancer chemotherapeutic agents in rodents on sensory processing, conditioned taste aversion, conditioned emotional response, passive avoidance, spatial learning, cued memory, discrimination learning, delayed-matching-to-sample, novel-object recognition, electrophysiological recordings and autoshaping is reviewed. It appears at first glance that the effects of the cancer chemotherapy agents in these many different models are inconsistent. However, a literature is emerging that reveals subtle or unique changes in sensory processing, acquisition, consolidation and retrieval that are dose- and time-dependent. As more studies examine cancer chemotherapeutic agents alone and in combination during repeated treatment regimens, the animal models will become more predictive tools for the assessment of these impairments and the underlying neural mechanisms. The eventual goal is to collect enough data to enable physicians to make informed choices about therapeutic regimens for their patients and discover new avenues of alternative or complementary therapies that reduce or eliminate chemotherapy-induced cognitive deficits.
AuthorsEllen A Walker
JournalAdvances in experimental medicine and biology (Adv Exp Med Biol) Vol. 678 Pg. 138-46 ( 2010) ISSN: 0065-2598 [Print] United States
PMID20738016 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • Antineoplastic Agents
Topics
  • Animals
  • Antineoplastic Agents (adverse effects, pharmacology, therapeutic use)
  • Memory (drug effects)
  • Models, Animal
  • Motor Activity (drug effects)
  • Neoplasms (drug therapy, physiopathology)
  • Sensation (drug effects)

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