Intratympanic prednisolone therapy for sudden sensorineural hearing loss: A new protocol.

Abstract

CONCLUSION:

Intratympanic administration of prednisolone at a dose of 62.5 mg/ml performed every day for 3 consecutive days is more efficacious than the therapeutic approaches described so far in the literature.

OBJECTIVES:

The aim of the study was to evaluate the overall success rate, morbidity, and prognostic factors of a new protocol of intratympanic steroid administration as a means of primary therapy for idiopathic sensorineural hearing loss.

METHODS:

Overall, 34 patients presenting sudden unilateral sensorineural hearing loss of at least 30 dB over three frequencies that had developed within 72 h were treated once a day for 3 consecutive days with a single intratympanic injection of prednisone diluted in saline solution.

RESULTS:

Following intratympanic therapy with prednisone, 16 patients (47%) reported complete recovery of sudden sensorineural hearing loss, with a pure tone average that returned within 25 dB; 11 patients (32.3%) showed improvement in hearing of more than 30 dB; 4 patients presented improvement in pure-tone average between 10 and 30 dB. Only three patients failed to improve following intratympanic injection.

• Authors: Roberto Filipo, Edoardo Covelli, Giorgio Balsamo, Giuseppe Attanasio
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 130 Issue 11 Pg. 1209-13 (Nov 2010) ISSN: 1651-2251 [Electronic] England
• PMID: 20735183 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids
• Prednisolone

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Audiometry, Pure-Tone
• Drug Administration Schedule
• Glucocorticoids (administration & dosage)
• Hearing Loss, Sensorineural (diagnosis, drug therapy)
• Hearing Loss, Sudden (diagnosis, drug therapy)
• Humans
• Middle Aged
• Prednisolone (administration & dosage)
• Prognosis
• Salvage Therapy
• Tympanic Membrane
• Young Adult