Prevalence of G6PD deficiency in a large cohort of HIV-infected patients.

Abstract

BACKGROUND:

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect. Screening for this condition in HIV-infected patients from susceptible ethnic groups is recommended based on expert opinion. Here we determined the prevalence of G6PD deficiency and the occurrence of G6PD-related hemolytic events in a large cohort of patients.

METHODS:

We identified all HIV-infected adults who presented as new patients at a single urban HIV clinic between 02/01/2007 and 01/31/2009. Demographic and laboratory data including G6PD results were collected. In addition, outpatient and inpatient medical records of G6PD deficient patients were reviewed for episodes of hemolytic anemia.

RESULTS:

A total of 1172 patients were identified and G6PD testing was performed in 1110 (94.7%). Overall, 75 (6.8%) subjects had G6PD deficiency. Rates were higher among African Americans (68/699; 9.7%) and Hispanics (5/253; 2.0%). Only one non-Hispanic White subject had G6PD deficiency (1/153; 0.7%). At baseline, hemoglobin concentrations were similar among subjects with or without G6PD deficiency. Among patients with G6PD deficiency, 40 (53.3%) were prescribed trimethoprim-sulfamethoxazole or dapsone. During follow-up, five (6.7%) of these patients developed acute hemolytic anemia.

DISCUSSION:

These results provide strong clinical evidence for recommending G6PD testing in HIV-infected subjects from susceptible ethnic backgrounds.

• Authors: Jose A Serpa, Erick Villarreal-Williams, Thomas P Giordano
• Journal: The Journal of infection (J Infect) Vol. 61 Issue 5 Pg. 399-402 (Nov 2010) ISSN: 1532-2742 [Electronic] England
• PMID: 20732351 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Infective Agents
• Drug Combinations
• Sulfamethizole
• trimethoprim sulfamethizole
• Dapsone
• Trimethoprim
• Glucosephosphate Dehydrogenase

Topics

• Adult
• Black or African American (statistics & numerical data)
• Aged
• Anemia, Hemolytic (complications, epidemiology)
• Anti-Infective Agents (therapeutic use)
• Cohort Studies
• Dapsone (therapeutic use)
• Drug Combinations
• Female
• Glucosephosphate Dehydrogenase (blood)
• Glucosephosphate Dehydrogenase Deficiency (blood, complications, drug therapy, epidemiology)
• HIV Infections (complications, epidemiology)
• Hispanic or Latino (statistics & numerical data)
• Humans
• Male
• Middle Aged
• Prevalence
• Sulfamethizole (therapeutic use)
• Texas (epidemiology)
• Trimethoprim (therapeutic use)
• Urban Population
• White People (statistics & numerical data)
• Young Adult