[The first experience of using rituximab in Mikulicz disease].

Abstract

The paper describes a case of Mikulicz's disease (MD) in a young woman (aged 19 years) with symmetrical large salivary gland lesion concurrent with the enlarged lacrimal glands. Immunomorphological and molecular studies of parotid gland biopsy specimens revealed the formation of MALT tissue without signs of B-cell clonality of an infiltrate. The diagnosis of lacrimal sac lymphoma was ruled out. MD was diagnosed. The use of rituximab in therapy for MD has first demonstrated a positive result in Russian and worldwide practice.

• Authors: V I Vasil'ev, S G Pal'shina, M V Simonova, O A Logvinenko, S Kh Sedyshev, B V Mitrikov, N A Probatova, N V Kokosadze, T N Safonova, E N Aleksandrova, E L Nasonov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 82 Issue 6 Pg. 62-6 ( 2010) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 20731115 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Antigens, CD
• Immunologic Factors
• Rituximab

Topics

• Adult
• Antibodies, Monoclonal, Murine-Derived (administration & dosage, therapeutic use)
• Antigens, CD (immunology)
• B-Lymphocytes (immunology)
• Biopsy
• Female
• Humans
• Immunohistochemistry
• Immunologic Factors (administration & dosage, therapeutic use)
• Mikulicz' Disease (diagnosis, diagnostic imaging, drug therapy, immunology, pathology)
• Radiography
• Rituximab
• Salivary Glands (immunology, pathology)
• T-Lymphocytes (immunology)
• Treatment Outcome