Human papillomavirus infection and anal dysplasia in renal transplant recipients.

Abstract

BACKGROUND:

Immunosuppression is a known risk factor for anal human papillomavirus (HPV) disease, including anal squamous cell carcinoma. Additional risk factors for HPV-related disease have not been studied in the renal transplant population. The demographics of anal HPV and associated risk factors were investigated in this population.

METHODS:

Anal cytology and polymerase chain reaction were used to assess anal HPV disease in a cohort of transplant recipients at the Royal London Hospital. Risk factors associated with increased immunosuppression and HPV exposure were collated to determine any association with anal disease.

RESULTS:

Anal dysplasia was associated with anal oncogenic HPV infection (P < 0.001), duration of immunosuppression (P = 0.050), previous genital warts (P = 0.018) and receptive anal intercourse (P = 0.013).

CONCLUSION:

Anal dysplasia was related to immunosuppression and patient factors in this cohort.

• Authors: H S Patel, A R Silver, T Levine, G Williams, J M Northover
• Journal: The British journal of surgery (Br J Surg) Vol. 97 Issue 11 Pg. 1716-21 (Nov 2010) ISSN: 1365-2168 [Electronic] England
• PMID: 20730855 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

Chemical References

• DNA

Topics

• Anal Canal (pathology)
• Anus Neoplasms (etiology)
• Carcinoma, Squamous Cell (etiology)
• DNA (analysis)
• Epidemiologic Methods
• Female
• Humans
• Immunosuppression Therapy (adverse effects)
• Kidney Transplantation
• Male
• Middle Aged
• Papillomavirus Infections (complications)
• Polymerase Chain Reaction
• Sexual Behavior