Abstract | OBJECTIVE: METHODS:
Intrauterine growth restriction was induced in Sprague-Dawley rats by isocaloric protein restriction in pregnant dams. IUGR pups were divided into two groups that were a standard- protein diet (IUGR group) or a high-protein diet (HP group). A comparative proteomic method was used to study the differences of protein expression profiles between normal adult rats and adult rats with IUGR and the effects of a postnatal high-protein diet on the protein expression profiles of the kidneys. RESULTS: The IUGR adults had higher urinary excretion of protein and blood pressure than controls and the HP diet caused more severe hypertension and proteinuria than IUGR itself. The differential proteomic expression analysis found 12 proteins that had significantly differential expression between the IUGR and control groups, which were transcription regulators and structural molecules. The differential proteomic expression analysis between the HP and control groups found 13 proteins that had significantly differential expression and were involved primarily in body metabolism, oxidation reduction, and apoptosis regulation. CONCLUSION:
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Authors | Qian Shen, Hong Xu, Li-Ming Wei, Jing Chen, Hai-Mei Liu |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 27
Issue 3
Pg. 364-71
(Mar 2011)
ISSN: 1873-1244 [Electronic] United States |
PMID | 20729036
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Dietary Proteins
- Transcription Factors
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Topics |
- Animals
- Animals, Newborn
- Apoptosis
(drug effects)
- Blood Pressure
(drug effects)
- Dietary Proteins
(adverse effects, metabolism, urine)
- Energy Metabolism
(drug effects)
- Female
- Fetal Growth Retardation
(etiology, metabolism)
- Hypertension
(chemically induced, metabolism)
- Kidney
(drug effects, metabolism)
- Kidney Diseases
(etiology, metabolism)
- Oxidation-Reduction
(drug effects)
- Pregnancy
- Proteinuria
(chemically induced, metabolism)
- Rats
- Rats, Sprague-Dawley
- Transcription Factors
(metabolism)
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