Risk factors for urinary tract infection after renal transplantation and its impact on graft function in children and young adults.

Abstract

PURPOSE:

Urinary tract infection will develop in 40% of children who undergo renal transplantation. Post-transplant urinary tract infection is associated with earlier graft loss in adults. However, the impact on graft function in the pediatric population is less well-known. Additionally the risk factors for post-transplant urinary tract infection in children have not been well elucidated. The purpose of this study was to assess the relationship between pre-transplant and post-transplant urinary tract infections on graft outcome, and the risk factors for post-transplant urinary tract infection.

MATERIALS AND METHODS:

A total of 87 patients underwent renal transplantation between July 2001 and July 2006. Patient demographics, cause of renal failure, graft outcome, and presence of pre-transplant and post-transplant urinary tract infections were recorded. Graft outcome was based on last creatinine and nephrological assessment.

RESULTS:

Median followup was 3.12 years. Of the patients 15% had pre-transplant and 32% had post-transplant urinary tract infections. Good graft function was seen in 60% of the patients and 21% had failed function. Graft function did not correlate with a history of pre-transplant or post-transplant urinary tract infection (p >0.2). Of transplanted patients with urological causes of renal failure 57% had post-transplant urinary tract infection, compared to only 20% of those with a medical etiology of renal failure (p <0.001).

CONCLUSIONS:

In this study there was no correlation between a history of urinary tract infection (either before or after transplant) and decreased graft function. History of pre-transplant urinary tract infection was suggestive of urinary tract infection after transplant. Patients with urological causes of renal failure may be at increased risk for post-transplant urinary tract infection.

• Authors: Andres Silva, Nancy Rodig, Carlo P Passerotti, Pedro Recabal, Joseph G Borer, Alan B Retik, Hiep T Nguyen
• Journal: The Journal of urology (J Urol) Vol. 184 Issue 4 Pg. 1462-7 (Oct 2010) ISSN: 1527-3792 [Electronic] United States
• PMID: 20727542 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Female
• Humans
• Kidney Transplantation (adverse effects, physiology)
• Male
• Retrospective Studies
• Risk Factors
• Urinary Tract Infections (epidemiology, etiology)