Pregnancy-associated plasma protein predicts outcomes of percutaneous coronary intervention in patients with non-ST-elevation acute coronary syndrome.

Abstract

OBJECTIVE:

Pregnancy-associated plasma protein A (PAPP-A) may play an important role in the development of acute coronary syndrome. This study aimed to investigate the relationship between the levels of circulating PAPP-A and the mid-term outcomes of percutaneous coronary intervention (PCI) in patients with non-ST-elevation acute coronary syndrome.

METHODS:

The circulating PAPP-A levels and high-sensitivity C-reactive protein before PCI were measured in 129 patients with single coronary artery stenosis. The end point of clinical follow-up was cardiac death, nonfatal myocardial infarction, target vessel revascularization, and rehospitalization for angina.

RESULTS:

During the follow-up of an average of 20.3 ± 5.2 months, a cardiac event was recorded in 25 patients (19.4%). The levels of PAPP-A (29.85 ± 19.51 mIu/L vs 20.47 ± 14.33 mIu/L, P = .007) and high-sensitivity C-reactive protein (5.63 ± 2.13 mg/L vs 4.11 ± 1.28 mg/L, P = .014) in patients with cardiac events were higher than in those without cardiac events. PAPP-A ≥ 11.33 mIu/L has a strong predictive value for a combined end point (risk ratio = 4.1; 95% confidence interval, 1.0-16.2; P = .037). Patients with lower PAPP-A levels (<11.33 mIu/L) had higher event-free survivals than patients with higher PAPP-A levels (log rank = 9.334, P = .025).

CONCLUSION:

Circulating PAPP-A levels predict the mid-term outcomes of PCI in patients with non-ST-elevation acute coronary syndrome and single-vessel stenosis.

• Authors: Wei-Yi Mei, Zhi-Min Du, Qiang Zhao, Cheng-Heng Hu, Yi Li, Chu-Fan Luo, Gui-Fu Wu, Guo-Wei Chen, Le-Xin Wang
• Journal: Heart & lung : the journal of critical care (Heart Lung) 2011 May-Jun Vol. 40 Issue 3 Pg. e78-83 ISSN: 1527-3288 [Electronic] United States
• PMID: 20723985 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Crown Copyright © 2011. Published by Mosby, Inc. All rights reserved.

Chemical References

• Pregnancy-Associated Plasma Protein-A

Topics

• Acute Coronary Syndrome (blood, mortality, therapy)
• Adult
• Aged
• Angina, Unstable (blood, mortality, therapy)
• Angioplasty, Balloon, Coronary
• China
• Confidence Intervals
• Coronary Stenosis (blood, mortality, therapy)
• Critical Care
• Female
• Humans
• Male
• Mathematical Computing
• Middle Aged
• Myocardial Infarction (blood, mortality, therapy)
• Odds Ratio
• Predictive Value of Tests
• Pregnancy-Associated Plasma Protein-A (metabolism)
• Prognosis
• Survival Analysis
• Treatment Outcome