Abstract | OBJECTIVES/HYPOTHESIS: STUDY DESIGN: Multicentered, prospective, randomized, placebo-controlled, parallel-group. METHODS: Three groups totaling 275 patients using: 1) fexofenadine alone, 2) fexofenadine with montelukast, or 3) fexofenadine with placebo, participated in a 21-day trial conducted during the spring pollen season. Objective analysis included pre- and poststudy physical examination findings and nasal resistance measurements. Subjective data gathered included a daily patient diary and pre- and poststudy patient satisfaction measurements. RESULTS: The group using both fexofenadine and montelukast showed significantly better control of nasal congestion both subjectively, using patient diary and visual analog scale evaluations, and objectively, using rhinomanometry and physical examination, compared to groups using antihistamine alone or with placebo. CONCLUSIONS:
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Authors | Cemal Cingi, Kivanc Gunhan, Linda Gage-White, Halis Unlu |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 120
Issue 9
Pg. 1718-23
(Sep 2010)
ISSN: 1531-4995 [Electronic] United States |
PMID | 20717951
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Acetates
- Anti-Allergic Agents
- Cyclopropanes
- Leukotriene Antagonists
- Quinolines
- Sulfides
- Terfenadine
- fexofenadine
- montelukast
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Topics |
- Acetates
(therapeutic use)
- Adult
- Airway Resistance
(drug effects)
- Anti-Allergic Agents
(therapeutic use)
- Case-Control Studies
- Cyclopropanes
- Drug Therapy, Combination
- Female
- Humans
- Leukotriene Antagonists
(therapeutic use)
- Male
- Pain Measurement
- Patient Satisfaction
- Quinolines
(therapeutic use)
- Rhinitis, Allergic, Perennial
(drug therapy, immunology)
- Rhinomanometry
- Sulfides
- Terfenadine
(analogs & derivatives, therapeutic use)
- Treatment Outcome
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