Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.

Abstract	Tetracycline, clindamycin, and other protein synthesis inhibitors at subinhibitory concentrations significantly increased the expression of the pivotal virulence regulator agr and production of the agr-regulated cytolytic phenol-soluble modulins in the community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain USA300. Our results suggest that such protein synthesis inhibitors may exacerbate the progression of CA-MRSA disease when applied at concentrations that are too low or when treating infections caused by strains resistant to those antibiotics.
Authors	Hwang-Soo Joo, June L Chan, Gordon Y C Cheung, Michael Otto
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 54 Issue 11 Pg. 4942-4 (Nov 2010) ISSN: 1098-6596 [Electronic] United States
PMID	20713669 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
Chemical References	Agr protein, Staphylococcus aureus Anti-Bacterial Agents Bacterial Proteins Bacterial Toxins Cytotoxins Protein Synthesis Inhibitors Trans-Activators staphylococcal delta toxin
Topics	Anti-Bacterial Agents (pharmacology) Bacterial Proteins (genetics) Bacterial Toxins (metabolism) Cytotoxins (metabolism) Methicillin-Resistant Staphylococcus aureus (drug effects, metabolism) Protein Synthesis Inhibitors (pharmacology) Reverse Transcriptase Polymerase Chain Reaction Trans-Activators (genetics) Virulence

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