Abstract | OBJECTIVES: METHODS: Ninety-three patients with APA were assessed for postoperative resolution of hypertension. All patients were genotyped for rs1799998 (C-344 T), intron 2 conversion, rs4539 (A2718G) within CYP11B2 and rs6410 (G22 5A), rs6387 (A2803G) within CYP11B1. The associations between CYPB11B2/ CYP11B1 polymorphisms and persistent postoperative hypertension were assessed by multivariate analysis. RESULTS: CYP11B2-CYP11B1 haplotype was associated with persistent postoperative hypertension in Chinese patients undergoing adrenalectomy with APA (P = .006). Specifically, the rs4539 (AA) polymorphism was associated with persistent postoperative hypertension (P = .002). Multivariate logistic regression revealed the common haplotypes H1 (AGACT), H2 (AGAWT), and H3 (AGAWC) were associated with the persistent postoperative hypertension (P = .01, 0.03, 0.005 after Bonferroni correction). Additional predictors of persistent postoperative hypertension included duration of hypertension (P <.0005), family history of hypertension (P = .001), and elevated systolic blood pressure (P = .015). CONCLUSIONS: The rs4539 (AA), H1, H2, and H3 are genetic predictors for postoperative persistence of hypertension for Chinese patients treated by adrenalectomy with APA. DNA polymorphisms at CYP11B2/B1 locus may confer susceptibility to postoperative hypertension of patients with APA.
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Authors | Baojun Wang, Guoxi Zhang, Jinzhi Ouyang, Xiyuan Deng, Taoping Shi, Xin Ma, Hongzhao Li, Zhenghua Ju, Chao Wang, Zhun Wu, Shuanglin Liu, Xu Zhang |
Journal | Urology
(Urology)
Vol. 76
Issue 4
Pg. 1018.e1-7
(Oct 2010)
ISSN: 1527-9995 [Electronic] United States |
PMID | 20708777
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Aldosterone
- Cytochrome P-450 CYP11B2
- Steroid 11-beta-Hydroxylase
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Topics |
- Adrenal Cortex Neoplasms
(epidemiology, genetics, metabolism, surgery)
- Adrenalectomy
- Adrenocortical Adenoma
(epidemiology, genetics, metabolism, surgery)
- Adult
- Aldosterone
(metabolism)
- China
(epidemiology)
- Cytochrome P-450 CYP11B2
(genetics)
- Exons
(genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Hyperaldosteronism
(epidemiology, etiology, genetics, surgery)
- Hypertension
(epidemiology, etiology, genetics)
- Introns
(genetics)
- Logistic Models
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Postoperative Complications
(epidemiology, etiology)
- Retrospective Studies
- Steroid 11-beta-Hydroxylase
(genetics)
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