HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Non-traumatic subarachnoid hemorrhage is associated with subnormal blood creatinine levels.

AbstractOBJECTIVE:
The aim of this study was to examine the hypothesis that patients with non-traumatic subarachnoid hemorrhage (SAH) have statistically significant subnormal creatinine levels and that the creatinine levels are associated with severity of disease.
MATERIALS AND METHODS:
This was a retrospective observational study over 2 years (2005-2006) in which the SAH patients were divided into patients with severe symptoms and patients with mild/moderate symptoms, and were compared to patients with; traumatic brain injury, trauma without brain injury and patients undergoing elective knee surgery. Blood creatinine levels (day 1-3, and day 7) were recorded.
RESULTS:
Compared to a normal distribution, SAH patients had statistically significant subnormal creatinine levels day one through seven. SAH patients with severe symptoms had statistically significant subnormal creatinine levels already on day one, in contrast to patients with mild/moderate symptoms. Women with severe symptoms had statistically significant subnormal creatinine levels throughout the study period in contrast to men with severe symptoms who had a normal distribution of creatinine at admission. Women with mild/moderate symptoms had a normal distribution of creatinine only at admission in contrast to men who had a normal distribution of creatinine throughout the study period. Male patients with traumatic brain injury, all trauma patients without brain injury and all patients undergoing elective knee surgery had a normal distribution of creatinine on all studied days.
CONCLUSIONS:
SAH is associated with subnormal serum creatinine levels. This finding is more pronounced in patients with severe symptoms and in women.
AuthorsIvana Kralova, Ola Winsö, Magnus Olivecrona, Silvana Naredi
JournalScandinavian journal of clinical and laboratory investigation (Scand J Clin Lab Invest) Vol. 70 Issue 6 Pg. 438-46 (Oct 2010) ISSN: 1502-7686 [Electronic] England
PMID20704519 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Creatinine
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Injuries (blood, physiopathology)
  • Creatinine (blood)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reference Values
  • Retrospective Studies
  • Sex Factors
  • Subarachnoid Hemorrhage (blood)
  • Trauma Severity Indices
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: