Abstract | OBJECTIVE: To evaluate vancomycin utilization according to the adapted criteria of the Centers for Disease Control and Prevention (CDC) with a report of the effect of education program on the utilization. METHOD: We evaluated the utilization of vancomycin over a 3-month period pre- and post-intervention using educational activity. RESULTS: In the pre-intervention period, of the 74 adult patients vancomycin was prescribed for specific treatment in 66% (n=49), empirical therapy in 26% (n=19) and as a prophylaxis in 8% (n=6). Vancomycin utilization was considered appropriate based on the CDC recommendations in 48 (65%) patients. Forty-seven (64%) patients received an appropriate dose regimen based on weight, age and creatinine clearance. Only 31% (n=23) of patients had both peak and trough levels taken around the third dose. In the post-intervention period, vancomycin was used as specific therapy in 41% (n=14) and empirically in 59% (n=20). Compliance with guidelines for empirical use of vancomycin improved from 21% in the pre-intervention phase to 85% after the intervention (P=.0001). In addition, compliance with vancomycin use in specific therapy was 100% compared to 82%. Compliance rate with vancomycin trough level monitoring increased from 35% in the pre-intervention period to 67.7% in the post-intervention period (P=0.0002). CONCLUSION: In conclusion, in addition to the utilization of CDC based criteria for vancomycin, we had shown that patient's chart review by a clinical pharmacists with a feed back to the physicians when guidelines were not met coupled with and educational efforts are effective methods to decrease inappropriate vancomycin usage.
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Authors | Jean G Dib, Jaffar A Al-Tawfiq, Saud Al Abdulmohsin, Khurram Mohammed, Phyllis D Jenden |
Journal | Journal of infection and public health
(J Infect Public Health)
Vol. 2
Issue 3
Pg. 141-6
( 2009)
ISSN: 1876-035X [Electronic] England |
PMID | 20701874
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Vancomycin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(blood, therapeutic use)
- Antibiotic Prophylaxis
(statistics & numerical data)
- Centers for Disease Control and Prevention, U.S.
- Cross Infection
(prevention & control)
- Drug Utilization
- Education, Medical, Continuing
- Female
- Guideline Adherence
- Humans
- Infection Control
(methods)
- Male
- Methicillin-Resistant Staphylococcus aureus
- Middle Aged
- Practice Guidelines as Topic
- Saudi Arabia
- Staphylococcal Infections
(prevention & control)
- United States
- Vancomycin
(blood, therapeutic use)
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