Abstract | INTRODUCTION: METHODS: The following databases were searched: Medline (period 2006-2008), Database of Abstract on Reviews and Effectiveness and Cochrane Database of Systematic Reviews. Reference lists of relevant articles were controlled for additional references. The search terms Review, Viscosupplementation (VS), Osteoarthritis (OA), Hyaluronic acid (HA), Hyaluronan, Sodium hyaluronate, Ankle OA, Ankle joint were used to identify all studies relating to the use of VS therapy for the ankle OA. Methodological quality of included studies was assessed by assigning level of evidence as previously defined by the Centre for Evidence Based Medicine (CEBM). RESULT: Seven articles concerning the efficacy of a total of 275 patients undergoing VS treatment for ankle OA were included. One European study, one Taiwanese study, one Italian study, one Turkish study and three American studies with level of evidence ranging from I to IV evaluated the following products: Hyalgan, Synvisc, Supartz, Adant. CONCLUSION:
Viscosupplementation is used widely in knee OA and is included in the professional guidelines for treatment of the disease in this joint. The potential for treating osteoarthritis of the ankle joint by viscosupplementation has been suggested in the literature, however, no dosing studies have been published to date, and dosing in the ankle joint remains an area for discussion. Viscosupplementation could potentially provide an useful alternative in treating such patients with painful ankle OA.
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Authors | Alberto Migliore, Francesca Giovannangeli, Emanuele Bizzi, Umberto Massafra, Andrea Alimonti, Bruno Laganà, Andrea Diamanti Picchianti, Valentina Germano, Mauro Granata, Prisco Piscitelli |
Journal | Archives of orthopaedic and trauma surgery
(Arch Orthop Trauma Surg)
Vol. 131
Issue 1
Pg. 139-47
(Jan 2011)
ISSN: 1434-3916 [Electronic] Germany |
PMID | 20697901
(Publication Type: Journal Article, Review)
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Chemical References |
- Viscosupplements
- hylan
- Hyaluronic Acid
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Topics |
- Ankle Joint
- Arthroscopy
- Humans
- Hyaluronic Acid
(administration & dosage, analogs & derivatives)
- Osteoarthritis
(surgery)
- Treatment Outcome
- Viscosupplementation
- Viscosupplements
(administration & dosage)
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