Abstract | OBJECTIVE: To investigate the prevalence, incidence, risk factors, and concomitants of Parkinson disease (PD)-associated psychosis (PDP) in a population-based prevalent cohort. DESIGN: Prospective longitudinal cohort study. SETTING: Community-based study in southwestern Norway. PARTICIPANTS: Two hundred thirty community-based PD patients were followed up prospectively for 12 years. Reassessments were conducted at 4 and 8 years and then annually. MAIN OUTCOME MEASURES: Severity of PDP was measured by the Unified Parkinson Disease Rating Scale thought disorder (UPDRS-TD) item. Patients with a UPDRS-TD score of 2 or more or those taking antipsychotic drugs owing to psychotic symptoms were categorized at each visit as having PDP. Generalized estimating equations were applied to investigate baseline risk factors for incident PDP and clinical and demographic concomitants of PDP during 12 years. RESULTS: CONCLUSIONS: Psychotic symptoms affect most patients with PD, with increased risk in those with higher age at onset, need for high doses of dopaminergic drugs, and probable REM sleep behavior disorder. This risk factor pattern and the observed associations with increased disability and dementia place PDP within a symptom complex signaling a malignant disease course.
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Authors | Elin B Forsaa, Jan Petter Larsen, Tore Wentzel-Larsen, Christopher G Goetz, Glenn T Stebbins, Dag Aarsland, Guido Alves |
Journal | Archives of neurology
(Arch Neurol)
Vol. 67
Issue 8
Pg. 996-1001
(Aug 2010)
ISSN: 1538-3687 [Electronic] United States |
PMID | 20697051
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiparkinson Agents
- Antipsychotic Agents
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Topics |
- Activities of Daily Living
- Aged
- Aged, 80 and over
- Antiparkinson Agents
(therapeutic use)
- Antipsychotic Agents
(therapeutic use)
- Cohort Studies
- Community Health Planning
- Female
- Humans
- Male
- Norway
(epidemiology)
- Parkinson Disease
(complications, drug therapy, epidemiology)
- Psychiatric Status Rating Scales
- Psychotic Disorders
(drug therapy, epidemiology, etiology)
- Risk Factors
- Severity of Illness Index
- Statistics, Nonparametric
- Time Factors
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