Abstract | INTRODUCTION: AIMS: The goal of this article is to review the published evidence for the use of axitinib in the treatment of thyroid cancer and define its therapeutic potential. EVIDENCE REVIEW: The major evidence of axitinib activity has appeared in meeting report abstracts. One phase II study has been published. This included patients with any histological type of thyroid cancer that was not amenable to treatment with radioactive iodine. CLINICAL POTENTIAL: To date, in phase II clinical studies axitinib has demonstrated antitumor activity in advanced refractory thyroid cancer. As a monotherapy it resulted in a 30% response rate with another 38% of patients having stable disease. Axitinib appears to have a good tolerability profile, with hypertension being the most common grade 3 or greater side effect.
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Authors | Hari A Deshpande, Scott Gettinger, Julie Ann Sosa |
Journal | Core evidence
(Core Evid)
Vol. 4
Pg. 43-8
(Jun 15 2010)
ISSN: 1555-175X [Electronic] New Zealand |
PMID | 20694064
(Publication Type: Journal Article)
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