Abstract | INTRODUCTION:
Chronic pancreatitis predisposes to diabetes. Loss of endocrine function by beta-cells in the Langerhans islets is considered to be the main causative factor, although several studies have also suggested insulin resistance as a possible additional mechanism. OBJECTIVES: PATIENTS AND METHODS: RESULTS: Diabetes was present in 22 patients, impaired glucose tolerance in 4, and no carbohydrate metabolism disturbances in 4. Insulin resistance was present in 22 patients (73.33%), in whom a higher prevalence of diabetes (77.27% vs. 62.5%) and prediabetes (13.63% vs. 12.5%) was observed. The analysis of anthropometric para meters revealed that individuals with a high index of central obesity had a statistically significantly lower tissue glucose utilization (TGU) (3.23 vs. 4.89 mg/kg/min; P = 0.02), although there were no obese patients in the study group according to the body mass index. No statistically significant differences in TGU were observed in relation to lipid disorders (total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides) and arterial hypertension. CONCLUSIONS:
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Authors | Agnieszka B Niebisz-Cieślak, Waldemar Karnafel |
Journal | Polskie Archiwum Medycyny Wewnetrznej
(Pol Arch Med Wewn)
Vol. 120
Issue 7-8
Pg. 255-63
(Jul 2010)
Poland |
PMID | 20693955
(Publication Type: Journal Article)
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Topics |
- Adult
- Female
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Pancreatitis, Alcoholic
(metabolism)
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