Dietary fatty acids and oxidative stress in the heart mitochondria.

Abstract

Our study compared the effects of different oils on oxidative stress in rat heart mitochondria, as well as on plasma parameters used as risk factors for cardiovascular disease. The rats were fed for 16 weeks with coconut, olive, or fish oil diet (saturated, monounsaturated, or polyunsaturated fatty acids, respectively). The cardiac mitochondria from rats fed with coconut oil showed the lowest concentration of oxidized proteins and peroxidized lipids. The fish oil diet leads to the highest oxidative stress in cardiac mitochondria, an effect that could be partly prevented by the antioxidant probucol. Total and LDL cholesterols decreased in plasma of rats fed fish oil, compared to olive and coconut oils fed rats. A diet enriched in saturated fatty acids offers strong advantages for the protection against oxidative stress in heart mitochondria.

• Authors: Hélène Lemieux, Anne Laure Bulteau, Bertrand Friguet, Jean-Claude Tardif, Pierre U Blier
• Journal: Mitochondrion (Mitochondrion) Vol. 11 Issue 1 Pg. 97-103 (Jan 2011) ISSN: 1872-8278 [Electronic] Netherlands
• PMID: 20691812 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Mitochondria Research Society. Published by Elsevier B.V. All rights reserved.

Chemical References

• Cholesterol, LDL
• Dietary Fats
• Fish Oils
• Olive Oil
• Plant Oils
• Cholesterol
• Coconut Oil

Topics

• Animals
• Cholesterol (blood)
• Cholesterol, LDL (blood)
• Coconut Oil
• Dietary Fats (administration & dosage, pharmacology)
• Fish Oils (administration & dosage, pharmacology)
• Lipid Peroxidation
• Male
• Mitochondria, Heart (drug effects, metabolism)
• Olive Oil
• Oxidative Stress (drug effects)
• Plant Oils (administration & dosage, pharmacology)
• Rats
• Rats, Sprague-Dawley