Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology.

Abstract

INTRODUCTION:

The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue.

METHODS:

One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression.

RESULTS:

The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%.

CONCLUSION:

MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.

• Authors: Robert C G Martin, Yan Li, Qiahong Liu, David F Barker, Mark A Doll, David W Hein
• Journal: Cancer investigation (Cancer Invest) Vol. 28 Issue 8 Pg. 813-9 (Oct 2010) ISSN: 1532-4192 [Electronic] England
• PMID: 20690800 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Superoxide Dismutase

Topics

• Adenocarcinoma (enzymology, genetics, pathology)
• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Adenosquamous (enzymology, genetics, pathology)
• Carcinoma, Squamous Cell (enzymology, genetics, pathology)
• Female
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Neoplastic
• Genotype
• Humans
• Immunohistochemistry
• Lung (enzymology)
• Lung Neoplasms (enzymology, genetics, pathology)
• Male
• Middle Aged
• Reference Values
• Superoxide Dismutase (genetics, metabolism)