Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery.

Abstract

BACKGROUND:

Epistaxis is the most common complication encountered during nasotracheal intubation (NTI) in children. The aim of this study was to test the efficacy of prophylactic intranasal admixture of xylometazoline and local anaesthetic gel in reducing epistaxis after NTI in children.

METHODS:

Children presenting for dental procedures requiring NTI were randomly allocated into two groups: Group 1 (xylometazoline group, n=53) and Group 2 (control group, n=51). After sevoflurane inhalation induction, the more patent nostril in each subject was lubricated with lidocaine 2% (1 ml) jelly, followed by 0.6 ml of either xylometazoline hydrochloride 0.1% nasal drops (Group 1) or sodium chloride 0.9% (Group 2). The presence and extent of bleeding occurring during intubation, extubation, or both and navigability through the nasal passage were assessed.

RESULTS:

The incidence and severity of bleeding were significantly reduced between the study group (7.5%) compared with the control group (27.5%; P<0.01). Navigability was similar in both groups.

CONCLUSIONS:

Admixture of intranasal xylometazoline 0.1% drops and lidocaine 2% jelly reduced the incidence and severity of epistaxis after NTI in preschool children.

• Authors: Z A El-Seify, A M Khattab, A A Shaaban, O S Metwalli, H E Hassan, L F Ajjoub
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 105 Issue 4 Pg. 501-5 (Oct 2010) ISSN: 1471-6771 [Electronic] England
• PMID: 20682569 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anesthetics, Local
• Imidazoles
• Vasoconstrictor Agents
• Lidocaine
• xylometazoline

Topics

• Administration, Intranasal
• Anesthesia, Dental (methods)
• Anesthetics, Local (administration & dosage)
• Child
• Child, Preschool
• Double-Blind Method
• Epistaxis (etiology, prevention & control)
• Female
• Humans
• Imidazoles (administration & dosage, therapeutic use)
• Intraoperative Care (methods)
• Intubation, Intratracheal (adverse effects, methods)
• Lidocaine (administration & dosage)
• Male
• Nasal Cavity
• Oral Surgical Procedures
• Vasoconstrictor Agents (administration & dosage, therapeutic use)