Nepafenac-assisted mydriasis in a rabbit model.

Abstract

PURPOSE:

To compare the effectiveness of nepafenac 0.10% in achieving and maintaining pupil dilation with the effectiveness of flurbiprofen 0.03% and a placebo in a rabbit model.

SETTING:

Department of Ophthalmology, University of California, San Francisco, California, USA.

DESIGN:

Laboratory study.

METHODS:

Adult pigmented rabbits were randomized to 3 equal-sized groups: placebo, flurbiprofen, and nepafenac. Cataract surgery was performed in randomized order by a surgeon who was masked to group assignment. The treatment or placebo was administered starting 1 day before surgery. Phenylephrine 10.0% was administered starting 30 minutes before surgery. Phacoemulsification was performed in standard fashion. Pupil measurements were recorded before and after surgery. A linear mixed model with a random effect for the rabbits and a fixed effect for the treatment groups was used to compare mean pupil diameters between groups.

RESULTS:

Baseline pupil measurements were similar between the placebo, flurbiprofen, and nepafenac groups. Preoperative pupil dilation was statistically significantly greater in the nepafenac group (mean 11.5 mm ± 0.5 [SD]) than in the placebo group (mean 10.2 ± 1.1 mm) and the flurbiprofen group (mean 9.9 ± 1.1 mm) (P<.005 and P<.001, respectively). The greater dilation was maintained at the end of surgery, at which time the nepafenac group had statistically significantly larger pupils (mean 9.4 ± 1.2 mm) than the placebo group (mean 7.9 ± 0.6 mm) and the flurbiprofen group (mean 8.5 ± 0.9 mm) (P<.001 and P<.05, respectively).

CONCLUSION:

Nepafenac was more effective than a placebo and flurbiprofen in achieving maximum preoperative and postoperative pupil mydriasis in rabbits.

• Authors: Michael K Yoon, Ayman Naseri, Travis Porco, Stephen D McLeod
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 36 Issue 10 Pg. 1779-82 (Oct 2010) ISSN: 1873-4502 [Electronic] United States
• PMID: 20674259 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Benzeneacetamides
• Mydriatics
• Phenylacetates
• nepafenac
• Flurbiprofen

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Benzeneacetamides (administration & dosage)
• Flurbiprofen (administration & dosage)
• Models, Animal
• Mydriatics (administration & dosage)
• Phacoemulsification
• Phenylacetates (administration & dosage)
• Pupil (drug effects)
• Rabbits
• Treatment Outcome