Abstract | BACKGROUND: METHODS: RESULT: All patients responded well to their joint affliction, but developed endogenous uveitis for the first time after application of etanercept. Following acute intervention with corticosteroids, etanercept was discontinued and instead an antibody-based anti-TNF treatment using infliximab was instituted. We documented visual acuity before and after change from etanercept to treatment with the anti- TNF-alpha antibody infliximab. Interestingly, prompt long-term remission (mean 34 months) of uveitis without recurrence could be induced in all patients. CONCLUSIONS: Our observations may indicate that immunodysregulatory and even proinflammatory effects of etanercept are of relevance in clinical practice. Further randomized controlled clinical trials are necessary to investigate possible side effects of anti-TNF therapy using etanercept and infliximab.
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Authors | Vinodh Kakkassery, Stefan Mergler, Uwe Pleyer |
Journal | Current eye research
(Curr Eye Res)
Vol. 35
Issue 8
Pg. 751-6
(Aug 2010)
ISSN: 1460-2202 [Electronic] England |
PMID | 20673052
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antirheumatic Agents
- Glucocorticoids
- Immunoglobulin G
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
- Infliximab
- Etanercept
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Monoclonal
(therapeutic use)
- Antirheumatic Agents
(adverse effects)
- Arthritis, Juvenile
(drug therapy)
- Etanercept
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Immunoglobulin G
(adverse effects)
- Infliximab
- Middle Aged
- Psoriasis
(drug therapy)
- Receptors, Tumor Necrosis Factor
- Spondylitis, Ankylosing
(drug therapy)
- Still's Disease, Adult-Onset
(drug therapy)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
- Uveitis
(chemically induced, drug therapy, physiopathology)
- Visual Acuity
(drug effects)
- Young Adult
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